Thursday, December 4, 2014

Herpes virus

        Herpes virus covers a large variaty of human diseases, and they are under the Herpesviridae family. Some of the virus from the family Herpesviridae are: 

  • Herpes simplex virus type 1 (HSV-1; species Human herpesvirus 1)
  • Herpes simplex virus type 2 (HSV-2; species Human herpesvirus 2)
  • Varicella Zoster virus (VZV; also known as Human Herpesvirus 3 - HHV3) 
  • Epstein-Barr virus (EBV; species Human herpesvirus 4)
  • Human herpes virus 6 (HHV-6)


        There are other species in the family Herpesviridae, but here we will focus in the first and second from the list above : HSV-1 and HSV-2

     Herpes simplex virus is a double stranded DNA virus that cause a common infection in humans. This infection is characterized by small watery blisters around lips and genital. The structure of this virus is an icosahedral capside and has an envelop. The genome encode approximatelly 100 proteins. Take a look below how the virus looks like:


By Bryan Brandenburg, March 9, 2013. (From http://bryanmbrandenburg.com/herpes-simplex-virus-3d-animation/)

       How the virus develop the lesions is explained in chapter 38 (Human diseases caused by viruses and prions) of Prescott's Microbiology p.871:

     "The herpesvirus genome must first enter an epitelial cell for the initiation of infection. The initial association is between proteoglycans of the epithelial cell surface and viral glycoproteins. This is followed by a specific interaction with one of several cellular receptors collectively termed HVEMs for herpesvirus entry mediators. The capside, along with some associated proteins, then migrates along the cellular microtubule transport machinery to nuclear envelope pores. This 'docking' is thought to result in the viral DNA being injected through the nuclear envelope pores while the capsid remains in the cytoplasm." 

       Since the virus starts being multiplied, the host cell metabolism is inhibited and the cell induces itself to apoptosis. This way the cell dies and new amounts of virus are released to infect new cells. Following we have an image of how the watery blisters looks like:


(From: http://www.edoctoronline.com/media/19/photos_Herpes_Labialis_25036.jpg)

       The transmission occurs by direct contact person to person, and initially was thought that HSV-1 infected most lips and oral mucosa and HSV-2 infected most genitals. Nonetheless, both virues can infect either tissue site. Once a person is infected with these viruses, he/she will be a host for lifetime, because our organism is not capable to eliminate the virus. It gets housed in trigeminal nerve ganglion.

      Conditions like emotional stress, excessive sunlight, fever, trauma, chilling and hormonal changes can reactivate the virus. Once reactivated, the virus moves from the nerve ganglion down a peripheral nerve and back to epithelial cells to produce the active phase.

       In United States, 70 to 90% of adults have been infected by type 1 herpes. The diagnosis can be made by ELISA and direct fluorescence antibody screening of tissue. There is no cure, but the control can be made using antiviral drugs like acyclovir and famciclovir.

       For now this is it!


(From www.condom.co.nz)

Prescott's MicrobiologyMcGraw-Hill Science/Engineering/Math; 9 edition (January 8, 2013)

5 comments:

  1. Hi Friends i am so glad to write this article today to tell the world how Dr Ekpiku cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr Ekpiku the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: ekpikuspellhomeofgrace@gmail.com i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr Ekpiku that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via: ekpikuspellhomeofgrace@hotmail.com or whatapps, call +2348073673757.

    ReplyDelete
  2. HOW I GOT CURED FROM HERPES SIMPLEX VIRUS:
    God bless Dr. Oloye for his marvelous work in my life, I was diagnosed of HERPES since 2014 and I was taking my medications, I wasn’t satisfied, i needed to get the HERPES out of my system, I was directed by my brother in-law to meet Dr.oloye who is good in curing HERPES DIABETES and CANCER with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS delivery service (UDS). I took the medicine as prescribed by him and 13 days later i was cured from HERPES, Dr. oloye truly you are great, do you need his help also?
    Why don’t you contact him through his
    email: droloyeherbalcure@gmail.com

    ReplyDelete
  3. There is another great option for herpes home remedy. It is simply because so many of us don't know the right one to meet at the right time . I was deadly in pain of herpes for six months, I tried different cure but it could not heal, one day my friend Jane saw a testimony of a lady'Edith' on this blog. how her herpes was cure by Dr Akhigbe with his herbal medicine cure that can help to heal the blister and sores of herpes totally.We write to him through his email, drrealakhigbe@gmail.com he told us that he was going to help us. He prepared the medicine and sent it to us through UPS courier services , he also instructed me on how i will be drinking the herbal medicine for three weeks. My dear brothers and sisters, Dr Akhigbe herbal medicine cure is real and it cure my herpes totally. So i must testify of him, he is a good man and i call him daddy.. If there any one out there that need his help because Dr Akhigbe cure different diseases.. Please contact him on his email... drrealakhigbe@gmail.com or you can also whatApp him with these number +2348142454860 Dr Akhigbe is good herbalist man to be trust..

    ReplyDelete
  4. There is another great option for herpes home remedy. It is simply because so many of us don't know the right one to meet at the right time . I was deadly in pain of herpes for six months, I tried different cure but it could not heal, one day my friend Jane saw a testimony of a lady'Edith' on this blog. how her herpes was cure by Dr Akhigbe with his herbal medicine cure that can help to heal the blister and sores of herpes totally.We write to him through his email, drrealakhigbe@gmail.com he told us that he was going to help us. He prepared the medicine and sent it to us through UPS courier services , he also instructed me on how i will be drinking the herbal medicine for three weeks. My dear brothers and sisters, Dr Akhigbe herbal medicine cure is real and it cure my herpes totally. So i must testify of him, he is a good man and i call him daddy.. If there any one out there that need his help because Dr Akhigbe cure different diseases.. Please contact him on his email... drrealakhigbe@gmail.com or you can also whatApp him with these number +2348142454860 Dr Akhigbe is good herbalist man to be trust..

    ReplyDelete
  5. I’m from USA am here to give my testimony about Dr Voke who helped me cure my HERPES (HSV), i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS), i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. Three months ago a friend suggested that I try herbal medicine; from a very powerful herbal doctor called (doctorvoke@gmail.com) I looked up his blog on the internet site and indeed he have had immense success with his product. There were lot of persons posting their testimony about how he cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, my HERPES result just came out negative. (doctorvoke@gmail.com)


    ReplyDelete